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Rivoceranib - HLB

Drug Profile

Rivoceranib - HLB

Alternative Names: Aitan; Apatinib; Apatinib mesylate; Apatinib Mesylate Tablets; YN-968-D1

Latest Information Update: 11 Mar 2024

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At a glance

  • Originator Advenchen Laboratories LLC
  • Developer Elevar Therapeutics; Henan Cancer Hospital; HLB LifeScience; Hunan Cancer Hospital; Jiangsu Hengrui Medicine Co.; Peking University
  • Class Amides; Antineoplastics; Cyclopentanes; Nitriles; Pyridines; Small molecules
  • Mechanism of Action Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer; Liver cancer; Adenoid cystic carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gastric cancer; Liver cancer
  • Phase III Fallopian tube cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer
  • Phase II Adenoid cystic carcinoma; Breast cancer; Cholangiocarcinoma; Colorectal cancer; Lung cancer; Malignant melanoma; Osteosarcoma; Small cell lung cancer; Soft tissue sarcoma; Solid tumours; Triple negative breast cancer; Uterine cancer
  • Phase I Oesophageal cancer

Most Recent Events

  • 18 Jan 2024 Adverse events data from a phase III CARES 310 trial in Liver cancer presented at the 2024 Gastrointestinal Cancers Symposium (ASCO-GCS-2024)
  • 20 Oct 2023 Efficacy and adverse event data from a phase I/II trial in Colorectal cancer presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)
  • 21 Sep 2023 Elevar Therapeutics plans to launch rivoceranib in USA
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