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Rivoceranib - HLB

Drug Profile

Rivoceranib - HLB

Alternative Names: Aitan; Apatinib; Apatinib mesylate; Apatinib Mesylate Tablets; YN-968-D1

Latest Information Update: 19 May 2023

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At a glance

  • Originator Advenchen Laboratories LLC
  • Developer Elevar Therapeutics; Henan Cancer Hospital; HLB LifeScience; Hunan Cancer Hospital; Jiangsu Hengrui Medicine Co.; Peking University
  • Class Amides; Antineoplastics; Cyclopentanes; Nitriles; Pyridines; Small molecules
  • Mechanism of Action Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer; Gastric cancer; Adenoid cystic carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gastric cancer
  • Registered Liver cancer
  • Phase III Fallopian tube cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer
  • Phase II Adenoid cystic carcinoma; Breast cancer; Cholangiocarcinoma; Colorectal cancer; Lung cancer; Malignant melanoma; Osteosarcoma; Small cell lung cancer; Soft tissue sarcoma; Solid tumours; Triple negative breast cancer; Uterine cancer
  • Phase I Oesophageal cancer

Most Recent Events

  • 17 May 2023 Preregistration for Liver cancer (Combination therapy, First-line therapy, Late-stage disease) in USA (PO)
  • 18 Apr 2023 Elevar Therapeutics plans to file an NDA and a BLA to the US FDA for the combination of rivoceranib plus camrelizumab for the treatment of Hepatocellular carcinoma the first half of 2023
  • 18 Apr 2023 Pharmacodynamics data from a preclinical study in Cancer released by Elevar Therapeutics
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