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Afatinib - Boehringer Ingelheim

Drug Profile

Afatinib - Boehringer Ingelheim

Alternative Names: BIBW 2992 MA2; BIBW-2992; Gilotrif; Giotrif; Tomtovok; Tovok; Xovoltib

Latest Information Update: 31 Jan 2019

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At a glance

  • Originator Boehringer Ingelheim
  • Developer Boehringer Ingelheim; European Organisation for Research and Treatment of Cancer; European Thoracic Oncology Platform; H. Lee Moffitt Cancer Center and Research Institute; Hanshin Oncology Group; Leiden University Medical Center; Okayama University; Translational Research In Oncology
  • Class Antineoplastics; Quinazolines; Radiation-sensitising agents; Small molecules
  • Mechanism of Action Epidermal growth factor receptor antagonists; ERBB 2 receptor antagonists; ERBB 4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer; CNS cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase III Breast cancer; Head and neck cancer
  • Phase II Chordoma; Glioma; Pancreatic cancer; Urogenital cancer
  • Phase I/II Rhabdomyosarcoma
  • Phase I Glioblastoma
  • No development reported Colorectal cancer; Prostate cancer; Solid tumours

Most Recent Events

  • 30 Nov 2018 University College, London and Boehringer Ingelheim completes the phase II TIMELY trial for Non small cell lung cancer in United Kingdom (NCT01415011)
  • 02 Nov 2018 Boehringer Ingelheim initiates a phase I trial in Head and neck cancer (Combination therapy, Metastatic disease, Recurrent, Second-line therapy or greater) in USA (PO) (NCT03652233)
  • 01 Nov 2018 Boehringer Ingelheim completes a phase II trial in Breast cancer (Combination therapy, Late-stage disease, First-line therapy, Metastatic disease) in Romania, Spain, USA, Bosnia-Herzegovina (PO) (NCT02115048)
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