Afatinib - Boehringer Ingelheim

Drug Profile

Afatinib - Boehringer Ingelheim

Alternative Names: BIBW 2992 MA2; BIBW-2992; Gilotrif; Giotrif; Tomtovok; Tovok; Xovoltib

Latest Information Update: 18 Jun 2018

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At a glance

  • Originator Boehringer Ingelheim
  • Developer Boehringer Ingelheim; European Organisation for Research and Treatment of Cancer; European Thoracic Oncology Platform; H. Lee Moffitt Cancer Center and Research Institute; Hanshin Oncology Group; Okayama University
  • Class Antineoplastics; Quinazolines; Radiation-sensitising agents; Small molecules
  • Mechanism of Action Epidermal growth factor receptor antagonists; ERBB 2 receptor antagonists; ERBB 4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer; CNS cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase III Breast cancer; Head and neck cancer
  • Phase II Glioma; Pancreatic cancer; Urogenital cancer
  • Phase I/II Rhabdomyosarcoma
  • Phase I Glioblastoma
  • No development reported Colorectal cancer; Prostate cancer; Solid tumours

Most Recent Events

  • 01 Jun 2018 Efficacy and adverse events data from a phase I trial in Glioblastoma presented at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO-2018)
  • 28 May 2018 No recent reports of development identified for phase-I development in Rhabdomyosarcoma(Second-line therapy or greater) in El Salvador (PO, Tablet)
  • 03 Apr 2018 Boehringer Ingelheim completes a phase II trial for Non-small cell lung cancer (EGFR mutation-positive, Late-stage disease, Metastatic disease) in Japan (PO) (UMIN000015847)
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