Ganetespib - Aldeyra Therapeutics

Drug Profile

Ganetespib - Aldeyra Therapeutics

Alternative Names: ADX 1612; SARC 023; STA-9090

Latest Information Update: 17 Aug 2018

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At a glance

  • Originator Synta Pharmaceuticals
  • Developer Aldeyra Therapeutics; Cancer Research UK; Cardiff University; Emory University; Innsbruck Medical University; Madrigal Pharmaceuticals; Memorial Sloan-Kettering Cancer Center; Multiple Myeloma Research Consortium; Synta Pharmaceuticals
  • Class Antineoplastics; Eye disorder therapies; Indoles; Resorcinols; Small molecules; Triazoles
  • Mechanism of Action HSP90 heat-shock protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Ovarian cancer
  • Phase I/II Mesothelioma
  • Phase I Lymphoproliferative disorders
  • Discontinued Acute myeloid leukaemia; Breast cancer; Chronic myeloid leukaemia; Colorectal cancer; Fallopian tube cancer; Gastric cancer; Gastrointestinal stromal tumours; Head and neck cancer; Hepatocellular carcinoma; Liver cancer; Malignant melanoma; Multiple myeloma; Myelodysplastic syndromes; Neuroendocrine tumours; Non-small cell lung cancer; Oesophageal cancer; Pancreatic cancer; Peritoneal cancer; Precursor cell lymphoblastic leukaemia-lymphoma; Prostate cancer; Rectal cancer; Sarcoma; Small cell lung cancer; Uveal melanoma

Most Recent Events

  • 17 Aug 2018 Ganetespib is still in clinical trials for Lymphoproliferative disorders, Ovarian cancer and Mesothelioma as of August 2018 (Aldeyra pipeline, August 2018)
  • 17 Aug 2018 Phase-I clinical trials in Lymphoproliferative disorders in USA (unspecified route) (Aldeyra pipeline, August 2018)
  • 16 Jul 2018 Discontinued - Phase-II for Uveal melanoma (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV)
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