Drug Profile

Carfilzomib - Onyx Pharmaceuticals

Alternative Names: Kyprolis; ONO-7057; PR-171

Latest Information Update: 14 Jun 2025

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At a glance

Originator Proteolix
Developer AbbVie; Amgen; Dana-Farber Cancer Institute; Genentech; GSK; Janssen Biotech; M. D. Anderson Cancer Center; Ohio State University Comprehensive Cancer Center; Ono Pharmaceutical; Onyx Pharmaceuticals; Phoenix Children's Hospital; Roswell Park Cancer Institute; The Innovative Therapies for Children with Cancer; Therapeutic Advances in Childhood Leukemia & Lymphoma; University of Alabama at Birmingham; University of Birmingham; University of California at San Francisco; University of California, Davis; University of Rochester; University of Texas M. D. Anderson Cancer Center
Class Antineoplastics; Epoxy compounds; Oligopeptides; Small molecules
Mechanism of Action Proteasome inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Multiple myeloma; Waldenstrom's macroglobulinaemia; Precursor cell lymphoblastic leukaemia-lymphoma
New Molecular Entity Yes
Available For Licensing Yes - Multiple myeloma

Marketed Multiple myeloma
Phase III Waldenstrom's macroglobulinaemia
Phase II Mantle-cell lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma; Prostate cancer; Renal cell carcinoma
Phase I/II Diffuse large B cell lymphoma; Peripheral T-cell lymphoma; Small cell lung cancer; Solid tumours
No development reported Leukaemia; Lymphoid leukaemia; Lymphoma; Non-Hodgkin's lymphoma; Systemic lupus erythematosus

28 Nov 2024 No recent reports of development identified for phase-I development in Multiple-myeloma in USA (IV, Infusion)
01 Oct 2024 Amgen completes the phase II SELECT trial in Multiple myeloma (Combination therapy, Second-line therapy or greater) in USA, Denmark, Estonia, France, Germany, Greece, Italy, Spain (IV) (NCT04191616) (EudraCT2019-001169-34)
28 Jun 2024 Onyx Pharmaceuticals completes the phase I/II trials in Precursor cell lymphoblastic leukaemia-lymphoma (Combination therapy, Monotherapy, In adolescents, In adults, In children, In infants, Second-line therapy or greater) in Turkey, Taiwan, Sweden, South Korea, Singapore, Russia, Romania, Portugal, Portugal, Poland, Hong Kong, Greece, Greece, Brazil, Bulgaria, Argentina, Thailand, South Africa, Saudi Arabia, Norway, Mexico, Czech Republic, Colombia, Chile (IV) (NCT02303821) (EudraCT2014-001633-84)

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