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Olesoxime - Roche

Drug Profile

Olesoxime - Roche

Alternative Names: Cholest-4-en-3-one,-oxime; Cholest-4-en-3-ylidenehydroxylamine; RG-6083; TRO-19622

Latest Information Update: 15 Mar 2019

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At a glance

  • Originator Trophos
  • Developer Roche; Trophos
  • Class Analgesics; Cholestenones; Hepatoprotectants; Neuroprotectants; Oximes; Small molecules
  • Mechanism of Action Mitochondrial permeability transition pore modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyotrophic lateral sclerosis; Spinal muscular atrophy
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Amyotrophic lateral sclerosis; Diabetic neuropathies; Huntington's disease; Multiple sclerosis; Neuropathic pain; Non-alcoholic steatohepatitis; Spinal muscular atrophy

Most Recent Events

  • 26 Jul 2018 Discontinued - Phase-II/III for Spinal muscular atrophy (In adolescents, In children, In adults) in Poland, France, Netherlands, Germany (PO) (Roche pipeline, July 2018)
  • 26 Jul 2018 Discontinued - Phase-II for Multiple sclerosis in France (PO) (Roche pipeline, July 2018)
  • 26 Jul 2018 Discontinued - Phase-II/III for Spinal muscular atrophy (In adolescents, In children, In adults) in Belgium (PO) (Roche pipeline, July 2018)
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