Drug Profile


Alternative Names: RG-6083; TRO-19622

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Trophos
  • Developer Roche; Trophos
  • Class Cholestenones; Neuroprotectants; Oximes; Small molecules
  • Mechanism of Action Apoptosis inhibitors; GABA A receptor modulators; Mitochondrial permeability transition pore modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyotrophic lateral sclerosis; Spinal muscular atrophy
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Spinal muscular atrophy
  • Phase II Multiple sclerosis
  • No development reported Huntington's disease
  • Discontinued Amyotrophic lateral sclerosis; Diabetic neuropathies; Neuropathic pain; Non-alcoholic steatohepatitis

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for preclinical development in Huntington's-disease in European Union (PO)
  • 19 Nov 2015 Phase-II/III clinical trials in Spinal muscular atrophy (In adolescents, In adults, In children) in United Kingdom, Belgium (PO)
  • 19 Nov 2015 Phase-II/III clinical trials in Spinal muscular atrophy (In children, In adolescents, In adults) in Italy (PO) (EudraCT2015-001589-25)
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