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Nalbuphine extended release - Trevi Therapeutics

Drug Profile

Nalbuphine extended release - Trevi Therapeutics

Alternative Names: Nalbuphine ER; Nalbuphine extended-release; PW-4142; T 111

Latest Information Update: 22 Jul 2019

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At a glance

  • Originator Penwest Pharmaceuticals
  • Developer Endo Pharmaceuticals; MentiNova; Rutgers; Trevi Therapeutics
  • Class Antitussives; Morphinans; Opioid analgesics; Small molecules
  • Mechanism of Action Opioid kappa receptor agonists; Opioid mu receptor antagonists; Opioid receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II/III Cough; Prurigo nodularis; Pruritus
  • Preclinical Drug-induced dyskinesia
  • Discontinued Pain

Most Recent Events

  • 23 Jul 2019 Trevi Therapeutics in collaboration with Parexel plans the CANAL phase II trial for Cough in patients comorbid with idiopathic pulmonary fibrosis in United kingdom, (NCT04030026)
  • 15 Jul 2019 Trevi Therapeutics suspends a phase I pharmacokinetic trial in patients with heaptic impairment in USA (NCT04020016)
  • 12 Jul 2019 Trevi Therapeutics temporarily suspends phase I trial evaluating abuse potential in Canada (NCT04018664)
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