Drug Profile

Secukinumab - Novartis

Alternative Names: AIN-457; Anti-interleukin 17A monoclonal antibody; Cosentyx; KB-03303A; Kosentikusu; NVP-AIN-457; Scapho

Latest Information Update: 25 Mar 2026

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At a glance

Originator Alcon; Novartis
Developer Beth Israel Deaconess Medical Center; GWT-TUD GmbH; Icahn School of Medicine at Mount Sinai; Novartis
Class Anti-inflammatories; Antiasthmatics; Antihyperglycaemics; Antipsoriatics; Antirheumatics; Eye disorder therapies; Monoclonal antibodies; Skin disorder therapies; Urologics; Vascular disorder therapies
Mechanism of Action IL17A protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Non-radiographic axial spondyloarthritis
New Molecular Entity Yes

Marketed Ankylosing spondylitis; Hidradenitis suppurativa; Non-radiographic axial spondyloarthritis; Plaque psoriasis; Psoriatic arthritis; Pustular psoriasis
Registered Juvenile rheumatoid arthritis
Phase III Graves ophthalmopathy; Polymyalgia rheumatica
Phase II Atopic dermatitis; Discoid lupus erythematosus; Necrobiosis lipoidica; SARS-CoV-2 acute respiratory disease; Tendon injuries
Discontinued Alopecia areata; Asthma; Crohn's disease; Dry eyes; Giant cell arteritis; Lichen planus; Lupus nephritis; Multiple sclerosis; Rheumatoid arthritis; Rotator cuff injuries; Type 1 diabetes mellitus; Uveitis

12 Mar 2026 Launched for Hidradenitis suppurativa (In adolescents) in USA (SC)
12 Mar 2026 Registered for Hidradenitis suppurativa (In adolescents) in USA (SC)
24 Feb 2026 Novartis Pharmaceuticals completes a phase III GigAINt trial in Giant cell arteritis in Germany (SC) (NCT05380453) (EudraCT2021-002622-24)

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