Secukinumab - Novartis

Drug Profile

Secukinumab - Novartis

Alternative Names: AIN-457; Anti-interleukin 17A monoclonal antibody; Cosentyx; KB-03303A; NVP-AIN-457; Scapho

Latest Information Update: 18 Oct 2018

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At a glance

  • Originator Alcon; Novartis
  • Developer Icahn School of Medicine at Mount Sinai; Novartis
  • Class Anti-inflammatories; Antiasthmatics; Antipsoriatics; Antirheumatics; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action IL17A protein inhibitors; IL17F protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Ankylosing spondylitis; Plaque psoriasis; Psoriatic arthritis
  • Registered Pustular psoriasis
  • Phase III Juvenile rheumatoid arthritis; Rheumatoid arthritis
  • Phase II Alopecia areata; Atopic dermatitis; Tendon injuries
  • Discontinued Asthma; Crohn's disease; Dry eyes; Multiple sclerosis; Polymyalgia rheumatica; Type 1 diabetes mellitus; Uveitis

Most Recent Events

  • 24 Sep 2018 Novartis completes a phase III trial in Ankylosing spondylitis in Japan (NCT02750592)
  • 17 Aug 2018 Novartis Pharma plans a phase III trial for Plaque Psoriasis in Estonia , (EudraCT2017-004515-39)
  • 20 Jul 2018 Novartis Pharmaceuticals plans a phase III MATURE trial for Plaque Psoriasis (Treatment-experienced) in October 2018 (NCT03589885)
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