Birabresib - OncoEthix
Alternative Names: MK 8628; OTX 015; Y-803Latest Information Update: 14 Jun 2024
At a glance
- Originator Mitsubishi Pharma Corporation
- Developer Merck & Co; Mitsubishi Tanabe Pharma Corporation; OncoEthix
- Class 3-ring heterocyclic compounds; Antineoplastics; Azepines; Small molecules; Triazoles
- Mechanism of Action BRD2 protein inhibitors; BRD3 protein inhibitors; BRD4 protein inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase II Solid tumours
- Phase I/II Glioblastoma
- Preclinical Urogenital cancer
- No development reported Haematological malignancies
- Discontinued Crohn's disease; Ulcerative colitis
Most Recent Events
- 05 Apr 2024 Pharmacodynamics data from preclinical studies in Glioblastoma presented at the 115th Annual Meeting of the American Association for Cancer Research (AACR-2024)
- 14 May 2023 Pharmacodynamics data from a preclinical study in Bladder cancer presented at the 114th Annual Meeting of the American Association for Cancer Research (AACR-2023)
- 27 Dec 2022 Preclinical development is ongoing in Urogenital cancer in Switzerland (Unspecified)