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Gevokizumab - Novartis

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Drug Profile

Gevokizumab - Novartis

Alternative Names: S-78989; VPM 087; XMA-005.2; XMA-0052; XOMA-052

Latest Information Update: 23 Mar 2025

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At a glance

  • Originator XOMA
  • Developer IRIS; National Eye Institute; North Shore-Long Island Jewish Health System; Novartis; Servier; University of Zurich; XOMA
  • Class Anti-inflammatories; Antiacnes; Antigouts; Antihyperglycaemics; Antineoplastics; Antirheumatics; Cardiovascular therapies; Eye disorder therapies; Immunotherapies; Monoclonal antibodies; Skin disorder therapies; Vascular disorder therapies
  • Mechanism of Action Interleukin 1 beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pyoderma; Uveitis; Behcet's syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Colorectal cancer; Gastric cancer; Oesophageal cancer; Renal cell carcinoma
  • Discontinued Acne vulgaris; Acute coronary syndromes; Diabetic nephropathies; Giant cell arteritis; Gout; Juvenile rheumatoid arthritis; Labyrinthitis; Myositis; Osteoarthritis; Pyoderma; Rheumatoid arthritis; Schnitzler syndrome; Scleritis; Type 1 diabetes mellitus; Type 2 diabetes mellitus; Uveitis

Most Recent Events

  • 05 Feb 2025 Novartis Pharmaceuticals completes a phase I clinical trials in Oesophageal cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in Czech Republic, Japan, Singapore, the UK, US, Australia, Belgium, Canada, Chile, Germany, Israel, Italy, South Korea, Spain and Taiwan (IV) (NCT03798626)
  • 23 Jul 2024 Discontinued - Phase-II for Acne vulgaris in USA (SC)
  • 23 Jul 2024 Discontinued - Phase-II for Acute coronary syndromes in Canada, Netherlands, Finland (SC)

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