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Gevokizumab - XOMA/Novartis

Drug Profile

Gevokizumab - XOMA/Novartis

Alternative Names: S-78989; VPM 087; XMA-005.2; XMA-0052; XOMA-052

Latest Information Update: 28 Jul 2020

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At a glance

  • Originator XOMA
  • Developer IRIS; National Eye Institute; North Shore-Long Island Jewish Health System; Novartis; Servier; University of Zurich; XOMA
  • Class Anti-inflammatories; Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Interleukin 1 beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pyoderma; Uveitis; Behcet's syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Uveitis
  • Phase II Acne vulgaris; Acute coronary syndromes; Diabetic nephropathies; Giant cell arteritis; Labyrinthitis; Myositis; Osteoarthritis; Schnitzler syndrome; Scleritis
  • Phase I Colorectal cancer; Gastric cancer; Oesophageal cancer; Renal cell carcinoma
  • Suspended Rheumatoid arthritis
  • No development reported Cancer; Gout; Juvenile rheumatoid arthritis; Type 1 diabetes mellitus; Type 2 diabetes mellitus
  • Discontinued Pyoderma

Most Recent Events

  • 22 Jul 2020 Novartis announces intention to submit regulatory applications for Colorectal cancer (First-line therapy) and Renal cell carcinoma (First-line therapy) in or after 2024
  • 22 Jun 2020 Pharmacodynamics data from a preclinical studies in Colorectal cancer presented at the 111th Annual Meeting of the American Association for Cancer Research (AACR-2020)
  • 22 May 2019 Phase-I clinical trials in Colorectal cancer (Combination therapy, First-line therapy, Metastatic disease) in United Kingdom, Singapore, Japan (IV) (NCT03798626)
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