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Olaparib - AstraZeneca

Drug Profile

Olaparib - AstraZeneca

Alternative Names: AZD 221; AZD-2281; KU-0059436; KU-59436; Lynparza; MK 7339

Latest Information Update: 23 May 2024

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At a glance

  • Originator KuDOS Pharmaceuticals; University of Pennsylvania
  • Developer AstraZeneca; Cancer Research UK; Dana-Farber Cancer Institute; European Network of Gynaecological Oncological Trial Groups; German Breast Group; Hospices Civils de Lyon; M. D. Anderson Cancer Center; Mario Negri Institute for Pharmacological Research; Massachusetts General Hospital; Merck & Co; Merck Sharp & Dohme; Myriad Genetic Laboratories; Myriad Genetics; National Cancer Institute (USA); National Institute of Oncology; Netherlands Cancer Institute; NHS Greater Glasgow and Clyde; Nordic Society of Gynaecological - Clinical Trial Unit; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Spanish Oncology Genito-Urinary Group; University Health Network; University of Manchester; University of Oxford; University of Sydney; University of Texas M. D. Anderson Cancer Center
  • Class Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Ketones; Phthalazines; Piperazines; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Fallopian tube cancer; Breast cancer; Pancreatic cancer; Peritoneal cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Fallopian tube cancer; HER2 negative breast cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer
  • Phase III Breast cancer; Colorectal cancer; Endometrial cancer; Non-small cell lung cancer; Small cell lung cancer; Squamous cell cancer
  • Phase II/III Triple negative breast cancer
  • Phase II Bladder cancer; Cervical cancer; Gastric cancer; Glioblastoma; Head and neck cancer; HER2 positive breast cancer; Osteosarcoma; Renal cell carcinoma; Solid tumours; Urogenital cancer

Most Recent Events

  • 11 Apr 2024 AstraZeneca completes a phase I trial for Solid tumours (Combination therapy; Late-stage disease) in Belgium, Netherlands and the UK (NCT00516724) (EuDraCT2007-000939-26)
  • 05 Apr 2024 Efficacy and adverse events data from a phase III KEYLYNK-008 trial in Non-small cell lung cancer presented 115th Annual Meeting of the American Association for Cancer Research, 2024 (AACR-2024)
  • 30 Jan 2024 Mirati Therapeutics initiates a phase Ib trial for Advanced solid tumors (Combination therapy, Late-stage disease, unresectable/Inoperable, Second-line therapy or greater) in the US (NCT06130254)
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