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Alternative Names:
AZD 221; AZD-2281; KU-0059436; KU-59436; Lynparza; MK 7339
Latest Information Update: 12 Jul 2021
Price :
$50
*
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We do not sell or distribute actual drugs.
Final gross price and currency may vary according to local VAT and billing address.
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At a glance
Originator
KuDOS Pharmaceuticals; University of Pennsylvania
Developer
AstraZeneca; Cancer Research UK; Dana-Farber Cancer Institute; European Network of Gynaecological Oncological Trial Groups; German Breast Group; M. D. Anderson Cancer Center; Mario Negri Institute for Pharmacological Research; Massachusetts General Hospital; Merck & Co; Merck Sharp & Dohme; Myriad Genetic Laboratories; Myriad Genetics; National Cancer Institute (USA); National Institute of Oncology; Netherlands Cancer Institute; NHS Greater Glasgow and Clyde; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Spanish Oncology Genito-Urinary Group; University Health Network; University of Manchester; University of Oxford; University of Sydney; University of Texas M. D. Anderson Cancer Center
Class
Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Ketones; Phthalazines; Piperazines; Small molecules
Mechanism of Action
Poly(ADP-ribose) polymerase inhibitors
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
Yes
-
Ovarian cancer; Fallopian tube cancer; Breast cancer; Pancreatic cancer; Peritoneal cancer
New Molecular Entity
Yes
Highest Development Phases
Marketed
Breast cancer; Fallopian tube cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer
Phase III
Colorectal cancer; Endometrial cancer; Non-small cell lung cancer; Small cell lung cancer; Squamous cell cancer
Phase II
Bladder cancer; Cervical cancer; Gastric cancer; Head and neck cancer; Osteosarcoma; Renal cell carcinoma; Solid tumours; Urogenital cancer
Phase I/II
Glioblastoma
Most Recent Events
30 Jun 2021
AstraZeneca and University of Oxford complete Phase-II clinical trials in Fallopian tube cancer, Ovarian cancer and Peritoneal cancer (Combination therapy, In adults, In adolescents) in United Kingdom (PO) (EudraCT2016-000559-28)
24 Jun 2021
Registered for Prostate cancer (Hormone refractory, Metastatic disease, Late-stage disease, Second-line therapy or greater, Monotherapy) in China (PO)
23 Jun 2021
Preregistration for Prostate cancer (Hormone refractory, Metastatic disease, Late-stage disease, Second-line therapy or greater, Monotherapy) in China (PO)
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