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Sparsentan - Travere Therapeutics

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Drug Profile

Sparsentan - Travere Therapeutics

Alternative Names: DARA; FILSPARI; PS-433540; RE-021

Latest Information Update: 28 May 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer CSL Vifor; Renalys Pharma; Retrophin; Travere Therapeutics
  • Class Anti-inflammatories; Antihypertensives; Isoxazoles; Nerve growth factors; Small molecules; Spiro compounds; Sulfonamides; Urologics; Vascular disorder therapies
  • Mechanism of Action Angiotensin type 2 receptor antagonists; Endothelin A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - IgA nephropathy; Focal segmental glomerulosclerosis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed IgA nephropathy
  • Preregistration Focal segmental glomerulosclerosis
  • Phase II Anti-neutrophil cytoplasmic antibody-associated vasculitis; Hereditary nephritis; Vasculitis
  • Discontinued Hypertension

Most Recent Events

  • 28 May 2025 Travere Therapeutics announces intention to hold an advisory committee meeting with the US FDA to discuss the application
  • 23 May 2025 CSL Vifor plans to launch Sparsentan in IgA nephropathy in United Kingdom (PO), in the second half of 2025
  • 23 May 2025 National Institute for Health and Care Excellence (NICE) recommends sparsentan for IgA nephropathy in England

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