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Trametinib - Novartis

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Drug Profile

Trametinib - Novartis

Alternative Names: 1120212; CE-Trametinib; GSK-1120212; GSK-1120212B; JTP-74057; Mecinist; Mekinist; Mekinisuto; Meqsel; Spexotras; Tasu Mekinisuto; TMT-212; Trametinib dimethyl sulfoxide; Trametinib DMSO

Latest Information Update: 25 Apr 2026

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At a glance

  • Originator Japan Tobacco
  • Developer BeOne Medicines; Bristol-Myers Squibb; Dana-Farber Cancer Institute; GlaxoSmithKline; GSK; Japan Tobacco; M. D. Anderson Cancer Center; Merck Sharp & Dohme; National Cancer Institute (USA); Novartis; Pfizer; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Amides; Antidementias; Antineoplastics; Cyclopropanes; Fluorobenzenes; Iodobenzenes; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action MAP kinase kinase 1 inhibitors; MAP kinase kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma; Glioma; Thyroid cancer; Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Glioma; Malignant melanoma; Non-small cell lung cancer; Solid tumours; Thyroid cancer
  • Registered Acral lentiginous melanoma
  • Phase II Acute myeloid leukaemia; Biliary cancer; Brain metastases; Cancer; Cervical cancer; Endometrial cancer; Multiple myeloma; Myeloid leukaemia; Pancreatic cancer; Triple negative breast cancer; Uveal melanoma
  • Phase I/II Colorectal cancer
  • No development reported Adenocarcinoma; Leukaemia; Lymphoma; Malignant-mesothelioma
  • Discontinued Inflammation

Most Recent Events

  • 26 Mar 2026 Preregistration for Malignant melanoma (Adjuvant therapy, Combination therapy, In adolescents, In adults, In the elderly, Late-stage disease) in European Union (PO) prior to March 2026
  • 26 Mar 2026 Preregistration for Malignant melanoma (In adolescents, In adults, In the elderly, Metastatic disease, Inoperable/Unresectable, Combination therapy) in European Union (PO) prior to March 2026
  • 26 Mar 2026 Preregistration for Malignant melanoma (In adolescents, In adults, In the elderly, Metastatic disease, Inoperable/Unresectable, Monotherapy) in European Union (PO) prior to March 2026

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