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Trametinib - Novartis

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Drug Profile

Trametinib - Novartis

Alternative Names: 1120212; CE-Trametinib; GSK-1120212; GSK-1120212B; JTP-74057; Mecinist; Mekinist; Mekinisuto; Meqsel; Spexotras; Tasu Mekinisuto; TMT-212; Trametinib dimethyl sulfoxide; Trametinib DMSO

Latest Information Update: 24 Jan 2025

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At a glance

  • Originator Japan Tobacco
  • Developer BeiGene; Bristol-Myers Squibb; Dana-Farber Cancer Institute; GlaxoSmithKline; GSK; Japan Tobacco; M. D. Anderson Cancer Center; Merck Sharp & Dohme; National Cancer Institute (USA); Novartis; Pfizer; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Amides; Antidementias; Antineoplastics; Cyclopropanes; Fluorobenzenes; Iodobenzenes; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action MAP kinase kinase 1 inhibitors; MAP kinase kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma; Glioma; Thyroid cancer; Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Glioma; Malignant melanoma; Non-small cell lung cancer; Solid tumours; Thyroid cancer
  • Registered Acral lentiginous melanoma
  • Phase II Acute myeloid leukaemia; Biliary cancer; Brain metastases; Cancer; Cervical cancer; Endometrial cancer; Multiple myeloma; Myeloid leukaemia; Pancreatic cancer; Triple negative breast cancer; Uveal melanoma
  • Phase I/II Colorectal cancer
  • Phase I Adenocarcinoma
  • No development reported Leukaemia; Lymphoma; Malignant-mesothelioma
  • Discontinued Inflammation

Most Recent Events

  • 07 Nov 2024 Novartis Pharmaceuticals completes a phase-II clinical trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease) in China (PO) (NCT04452877)
  • 16 Jul 2024 Launched for Malignant melanoma (Combination therapy, First-line therapy, Metastatic disease) in Australia (PO) before July 2024
  • 16 Jul 2024 Launched for Malignant melanoma (Inoperable/Unresectable, Metastatic disease, Monotherapy) in Australia (PO) before July 2024

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