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Research programme: monoclonal antibody therapeutics - AVEO

Drug Profile

Research programme: monoclonal antibody therapeutics - AVEO

Alternative Names: AV-232; AV-323; AV-325; AV-353; AV-368; AV-369; AV-370; AV-371; AV-378; AV-380

Latest Information Update: 15 May 2019

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At a glance

  • Originator St Vincents Hospital, Sydney
  • Developer AVEO Oncology
  • Class Monoclonal antibodies
  • Mechanism of Action Growth differentiation factor 15 inhibitors; Hepatocyte growth factor inhibitors; Immunomodulators; Notch signalling pathway inhibitors; Notch-3 receptor antagonists; Proto oncogene protein c met inhibitors; RON protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes - Cachexia; Pulmonary arterial hypertension

Highest Development Phases

  • Preclinical Cachexia; Cancer; Pulmonary arterial hypertension

Most Recent Events

  • 15 May 2019 AV-380 is still in preclinical trials for Cachexia in USA (Parenteral)
  • 23 Apr 2019 AVEO Pharmaceuticals plans IND-enabling toxicology studies in Cachexia in mid-2019
  • 05 Mar 2019 AVEO Pharmaceuticals plans clinical development in Cachexia
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