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Ganitumab - Amgen

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Drug Profile

Ganitumab - Amgen

Alternative Names: AMG-479

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Amgen
  • Developer Amgen; Dana-Farber Cancer Institute; Millennium; NantWorks; National Cancer Institute (USA); Novartis; Takeda; Takeda Oncology; UCLAs Jonsson Comprehensive Cancer Center
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action IGF type 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ewing's sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Colorectal cancer; Ewing's sarcoma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Rhabdomyosarcoma; Sarcoma; Small cell lung cancer; Solid tumours

Most Recent Events

  • 06 Dec 2022 Discontinued - Clinical-Phase-Unknown for Ewing's Sarcoma (Metastatic disease, Monotherapy, Second-line therapy or greater) in USA (IV)
  • 06 Dec 2022 Discontinued - Phase-I for Solid tumours (Late-stage disease) in Japan (IV)
  • 06 Dec 2022 Discontinued - Phase-I/II for Colorectal cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in Canada, Australia, Australia (IV)

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