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Lobeglitazone - Chong Kun Dang

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Drug Profile

Lobeglitazone - Chong Kun Dang

Alternative Names: CKD-501; Duvie; Lobeglitazone sulfate; M-107

Latest Information Update: 01 Dec 2025

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At a glance

  • Originator Chong Kun Dang
  • Developer Aclipse Therapeutics; Chong Kun Dang; EQUIS & ZAROO
  • Class Antihyperglycaemics; Gastrokinetics; Pyrimidines; Small molecules; Thiazolidinediones
  • Mechanism of Action Peroxisome proliferator-activated receptor alpha agonists; Peroxisome proliferator-activated receptor gamma agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Type 2 diabetes mellitus
  • Phase I Gastroparesis

Most Recent Events

  • 24 Nov 2025 Aclipse Therapeutics and Mayo Clinic agrees collaboration for phase II trial of M107 for Gastroparesis
  • 17 Nov 2025 Aclipse Therapeutics in collaboration with Mayo Clinic plans a phase II LOGAST trial for Gastroparesis in first quarter of 2026
  • 24 Sep 2025 Aclipse Therapeutics has patents pending for lobeglitazonein (Aclipse Therapeutics pipeline, September 2025)

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