Ivacaftor - Vertex Pharmaceuticals

Drug Profile

Ivacaftor - Vertex Pharmaceuticals

Alternative Names: IVA; Kalydeco; Potentiator VX-770; VRT 813077; VX-770

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Cystic Fibrosis Foundation Therapeutics; Vertex Pharmaceuticals
  • Developer Vertex Pharmaceuticals
  • Class Amides; Aminophenols; Quinolones; Small molecules
  • Mechanism of Action Cystic fibrosis transmembrane conductance regulator stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cystic fibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cystic fibrosis
  • Phase II Chronic obstructive pulmonary disease

Most Recent Events

  • 01 Jan 2018 Vertex completes a phase II trial for Cystic fibrosis (Combination therapy) in USA (PO) (NCT02951195)
  • 07 Dec 2017 Vertex plans to submit applications for Cystic fibrosis (In infants, In neonates) to the US Food and Drug Administration and the European Medicines Agency in the first quarter of 2018
  • 07 Dec 2017 Safety and efficacy data from a phase III clinical trial Cystic fibrosis released by Vertex
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