Ivacaftor - Vertex Pharmaceuticals

Drug Profile

Ivacaftor - Vertex Pharmaceuticals

Alternative Names: IVA; Kalydeco; Potentiator VX-770; VRT 813077; VX-770

Latest Information Update: 13 Nov 2018

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At a glance

  • Originator Cystic Fibrosis Foundation Therapeutics; Vertex Pharmaceuticals
  • Developer Vertex Pharmaceuticals
  • Class Amides; Aminophenols; Quinolones; Small molecules
  • Mechanism of Action Cystic fibrosis transmembrane conductance regulator stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cystic fibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cystic fibrosis
  • Phase II Chronic obstructive pulmonary disease

Most Recent Events

  • 01 Nov 2018 Registered for Cystic fibrosis (Combination therapy, In adolescents, In the elderly, In adults) in European Union, Norway, Iceland and Liechtenstein (PO)
  • 01 Nov 2018 Pooled efficacy and adverse events data from the phase III EVOLVE and EXPAND trials in Cystic fibrosis released by Vertex Pharmaceuticals
  • 24 Oct 2018 Vertex Pharmaceuticals expects a decision for approval of ivacaftor from the EMA for cystic fibrosis (in infants) in late 2018
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