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ME 344

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Drug Profile

ME 344

Alternative Names: ME-344; NV-344

Latest Information Update: 16 May 2024

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At a glance

  • Originator Novogen
  • Developer MEI Pharma; Sarah Cannon Research Institute; Spanish National Cancer Research Centre; Tennessee Oncology
  • Class Antineoplastics; Isoflavones; Small molecules
  • Mechanism of Action Mitochondrial oxidative phosphorylation inhibitors; MTORC1 protein inhibitors; MTORC2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Colorectal cancer
  • Preclinical Acute myeloid leukaemia
  • No development reported HER2 negative breast cancer
  • Discontinued Cervical cancer; Ovarian cancer; Small cell lung cancer

Most Recent Events

  • 09 May 2024 MEI Pharma anticipates to provide an update on new formulation of ME 344, in 1H of 2025
  • 11 Apr 2024 Interim adverse events and efficacy data from a phase-I trial in Colorectal cancer released by MEI Pharma
  • 08 May 2023 Phase-I clinical trials in Colorectal cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in USA (IV) (NCT05824559)

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