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Ofranergene obadenovec - Notable Labs

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Drug Profile

Ofranergene obadenovec - Notable Labs

Alternative Names: GT-111; ofra-vec; VB 111

Latest Information Update: 04 Sep 2024

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At a glance

  • Originator Vascular Biogenics
  • Developer Gynecologic Oncology Group; Massachusetts General Hospital; National Cancer Institute (USA); Notable Labs
  • Class Antineoplastics; Gene therapies; Immunotherapies
  • Mechanism of Action Angiogenesis modulating agents; Gene transference; Vascular disrupting agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Glioblastoma
  • New Molecular Entity No

Highest Development Phases

  • Discontinued Colorectal cancer; Glioblastoma; Lung cancer; Malignant melanoma; Ovarian cancer; Thyroid cancer

Most Recent Events

  • 04 Sep 2024 VBL Therapeutics terminated phase-II clinical trials in Glioblastoma (Late-stage disease, Second-line therapy or greater) in USA due to discontinuation of candidate(NCT04406272)
  • 02 Jun 2023 Efficacy and adverse events data from a phase III OVAL trial for Ovarian cancer presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
  • 31 Dec 2022 ofranergene obadenovec is no longer licensed to NanoCarrier in Japan

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