Ofranergene obadenovec - Notable Labs
Alternative Names: GT-111; ofra-vec; VB 111Latest Information Update: 04 Sep 2024
At a glance
- Originator Vascular Biogenics
- Developer Gynecologic Oncology Group; Massachusetts General Hospital; National Cancer Institute (USA); Notable Labs
- Class Antineoplastics; Gene therapies; Immunotherapies
- Mechanism of Action Angiogenesis modulating agents; Gene transference; Vascular disrupting agents
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- Discontinued Colorectal cancer; Glioblastoma; Lung cancer; Malignant melanoma; Ovarian cancer; Thyroid cancer
Most Recent Events
- 04 Sep 2024 VBL Therapeutics terminated phase-II clinical trials in Glioblastoma (Late-stage disease, Second-line therapy or greater) in USA due to discontinuation of candidate(NCT04406272)
- 02 Jun 2023 Efficacy and adverse events data from a phase III OVAL trial for Ovarian cancer presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
- 31 Dec 2022 ofranergene obadenovec is no longer licensed to NanoCarrier in Japan