Ofranergene obadenovec - VBL Therapeutics

Drug Profile

Ofranergene obadenovec - VBL Therapeutics

Alternative Names: GT-111; VB 111

Latest Information Update: 28 May 2018

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At a glance

  • Originator Vascular Biogenics
  • Developer Gynecologic Oncology Group; Massachusetts General Hospital; VBL Therapeutics
  • Class Antineoplastics; Gene therapies
  • Mechanism of Action Angiogenesis modulating agents; Gene expression modulators; Vascular disrupting agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Glioblastoma
  • New Molecular Entity No

Highest Development Phases

  • Phase III Glioblastoma; Ovarian cancer
  • Phase II Thyroid cancer
  • Preclinical Lung cancer; Malignant melanoma

Most Recent Events

  • 08 Mar 2018 Primary endpoint was not met in the top-line efficacy data from the phase III GLOBE trial in Glioblastoma released by VBL Therapeutics
  • 27 Dec 2017 Phase-III clinical trials in Ovarian cancer (Second-line therapy or greater, Combination therapy) in Israel (IV) after December 2017 (NCT03398655)
  • 27 Dec 2017 Phase-III clinical trials in Ovarian cancer (Second-line therapy or greater, Combination therapy) in USA (IV) (NCT03398655)
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