Glembatumumab vedotin - Celldex Therapeutics Inc

Drug Profile

Glembatumumab vedotin - Celldex Therapeutics Inc

Alternative Names: CDX-011; CR 011 ADC; CR 011-vcMMAE; CR011-vcMMAE immunotoxin; Glemba; Glembatumumab; GV

Latest Information Update: 18 Apr 2018

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At a glance

  • Originator CuraGen Corporation
  • Developer Celldex Therapeutics Inc; National Cancer Institute (USA)
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Brain cancer; Breast cancer; Malignant melanoma; Osteosarcoma; Squamous cell cancer; Uveal melanoma

Most Recent Events

  • 16 Apr 2018 Discontinued - Phase-I/II for Squamous cell cancer (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV)
  • 16 Apr 2018 Discontinued - Phase-II for Breast cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA, Australia, Canada, Spain, United Kingdom, Belgium, France, Germany, Italy (IV)
  • 16 Apr 2018 Discontinued - Phase-II for Malignant melanoma (Combination therapy, Inoperable/Unresectable, Late-stage disease) in USA (IV)
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