Serlopitant - Menlo Therapeutics

Drug Profile

Serlopitant - Menlo Therapeutics

Alternative Names: JTS 661; MK-0594; Serlopitant -Menlo Therapeutics; VPD-737

Latest Information Update: 11 Jul 2018

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At a glance

  • Originator Merck & Co
  • Developer Epidermolysis Bullosa Research Partnership; Japan Tobacco; Menlo Therapeutics; Merck & Co; Stanford University; Torii Pharmaceutical; Velocity Pharmaceutical Development
  • Class Antipruritics; Antitussives; Cyclopentanes; Isoindoles; Skin disorder therapies; Small molecules; Urologics
  • Mechanism of Action Neurokinin 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Pruritus
  • Phase II Cough; Prurigo nodularis
  • Discontinued Alcoholism; Overactive bladder

Most Recent Events

  • 01 Aug 2018 Menlo Therapeutics plans a phase II trial in chronic Pruritus of unknown origin in 4Q 2018, based on retrospective analyses of completed phase II trials
  • 29 Jun 2018 Japan Tobacco and Torii Pharamceuticals terminates its Development and marketing agreement with Menlo Therapeutics for serlopitant in Japan
  • 29 Jun 2018 Discontinued - Phase-II for Pruritus (In the elderly, In adults) in Japan (PO) (JapicCTI-173781)
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