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Gefapixant - Merck & Co

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Drug Profile

Gefapixant - Merck & Co

Alternative Names: AF-219; Gefapixant citrate - Merck & Co; LYFNUA; Lyfnua; MK-7264; R 1646; RG-1646; RO-4926219

Latest Information Update: 01 Oct 2026

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At a glance

  • Originator Roche
  • Developer Merck & Co; Roche
  • Class Amines; Analgesics; Antiasthmatics; Antitussives; Benzene derivatives; Ethers; Pyrimidines; Sleep disorder therapies; Small molecules; Sulfonamides
  • Mechanism of Action Purinergic P2X3 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cough
  • Discontinued Asthma; Interstitial cystitis; Musculoskeletal pain; Overactive bladder; Pain; Pelvic pain; Sleep apnoea syndrome

Most Recent Events

  • 31 Dec 2024 Withdrawn - Preregistration for Cough in USA (PO)
  • 20 Dec 2023 Merck & Co receives complete response letter from the US FDA for gefapixant in Cough
  • 15 Sep 2023 Registered for Cough in European Union (PO)

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