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Gefapixant - Merck & Co

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Drug Profile

Gefapixant - Merck & Co

Alternative Names: AF-219; Gefapixant citrate - Merck & Co; Gefzuris; LYFNUA; MK-7264; R 1646; RG-1646; RO-4926219

Latest Information Update: 06 Sep 2024

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At a glance

  • Originator Roche
  • Developer Merck & Co; Roche
  • Class Amines; Analgesics; Antiasthmatics; Antitussives; Benzene derivatives; Ethers; Pyrimidines; Sleep disorder therapies; Small molecules; Sulfonamides
  • Mechanism of Action Purinergic P2X3 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Cough
  • Discontinued Asthma; Interstitial cystitis; Musculoskeletal pain; Overactive bladder; Pain; Pelvic pain; Sleep apnoea syndrome

Most Recent Events

  • 20 Dec 2023 Merck & Co receives complete response letter from the US FDA for gefapixant in Cough
  • 31 Jul 2023 US FDA accepts Merck’s resubmission of the NDA for gefapixant in Cough in USA, following the company’s response to the complete response letter (Merck & Co pipeline, August 2023).
  • 21 Jul 2023 Merck expects the EC decision on approval of gefapixant for Cough in late 2023

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