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Gefapixant - Merck & Co

Drug Profile

Gefapixant - Merck & Co

Alternative Names: AF-219; MK-7264; R1646; RG-1646; RO 4926219

Latest Information Update: 18 Nov 2019

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At a glance

  • Originator Roche
  • Developer Merck & Co; Roche
  • Class Analgesics; Antiasthmatics; Antitussives; Pyrimidines; Small molecules; Sulfonamides; Urologics
  • Mechanism of Action Purinergic P2X3 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Cough
  • Phase II Asthma; Interstitial cystitis; Musculoskeletal pain; Pelvic pain
  • Phase I Sleep apnoea syndrome
  • Discontinued Overactive bladder; Pain

Most Recent Events

  • 22 Oct 2019 Merck Sharp & Dohme completes a phase I trial in Sleep apnoea syndrome in USA and Belgium (NCT03882801)
  • 20 May 2019 Efficacy and adverse events data from a phase II trial in Cough (Associated with Idiopathic Pulmonary Fibrosis)indication) presented at the 115th International Conference of the American Thoracic Society (ATS-2019)
  • 10 Apr 2019 Phase-I clinical trials in Sleep apnoea syndrome in USA (PO) (NCT03882801)
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