Gefapixant - Merck

Drug Profile

Gefapixant - Merck

Alternative Names: AF-219; MK-7264; R1646; RG-1646; RO 4926219

Latest Information Update: 06 Apr 2018

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At a glance

  • Originator Roche
  • Developer Merck & Co; Roche
  • Class Analgesics; Antiasthmatics; Antitussives; Pyrimidines; Small molecules; Sulfonamides; Urologics
  • Mechanism of Action Purinergic P2X3 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Cough
  • Phase II Asthma; Interstitial cystitis; Musculoskeletal pain
  • Discontinued Overactive bladder; Pain

Most Recent Events

  • 26 Mar 2018 Phase-III clinical trials in Cough in Denmark, Germany (PO) (EudraCT2017-003559-49)
  • 26 Mar 2018 Phase-III clinical trials in Cough in USA (PO) (NCT03449134)
  • 26 Mar 2018 Merck initiates enrolment in the MK-7264-030 phase III trial for Cough in USA (PO) (NCT03449147)
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