Omecamtiv mecarbil - Amgen/Cytokinetics

Drug Profile

Omecamtiv mecarbil - Amgen/Cytokinetics

Alternative Names: AMG-423; CK-1827452; CK-452

Latest Information Update: 09 Nov 2018

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At a glance

  • Originator Cytokinetics
  • Developer Amgen; Cytokinetics; Servier
  • Class Esters; Heart failure therapies; Organic chemicals; Piperazines; Pyridines; Small molecules
  • Mechanism of Action Cardiac myosin stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic heart failure
  • Phase II Acute heart failure; Heart failure
  • No development reported Angina pectoris; Cardiomyopathies

Most Recent Events

  • 26 Apr 2018 Amgen and Cytokinetics plan the phase III METEORIC-HF trial in Heart failure by the end of 2018
  • 18 Sep 2017 Pharmacodynamics data from the phase III COSMIC-HF trial Chronic heart failure released by Cytokinetics
  • 08 May 2017 Amgen completes the phase II trial in Heart failure in Japan (NCT02695420)
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