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OBI 3424

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Drug Profile

OBI 3424

Alternative Names: AST-3424; OBI-3424; TH-3424

Latest Information Update: 05 Jan 2026

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At a glance

  • Originator Threshold Pharmaceuticals
  • Developer Ascentawits Pharmaceuticals; National Cancer Institute (USA); OBI Pharma; Zhejiang Hisun Pharmaceutical
  • Class Antineoplastics; Aziridines; Benzamides; Benzene derivatives; Ethers; Nitro compounds; Phosphorus compounds; Small molecules
  • Mechanism of Action AKR1C3 protein inhibitors; DNA cross linking agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Precursor cell lymphoblastic leukaemia-lymphoma; Liver cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Liver cancer; Precursor T-cell lymphoblastic leukaemia-lymphoma
  • Phase I/II Pancreatic cancer; Solid tumours

Most Recent Events

  • 30 Dec 2025 Phase-II clinical trials in Liver cancer (Late-stage disease, Second-line therapy or greater) in China (IV) (NCT07310173)
  • 25 Apr 2025 Pharmacodynamic data from a preclinical trial in Solid tumors presented at the 116th Annual Meeting of the American Association for Cancer Research(AACR-2025)
  • 25 Apr 2025 Pharmacodynamics and adverse events data from preclinical trial in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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