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OBI 3424

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Drug Profile

OBI 3424

Alternative Names: AST-3424; OBI-3424; TH-3424

Latest Information Update: 18 Jun 2024

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At a glance

  • Originator Threshold Pharmaceuticals
  • Developer Ascentawits Pharmaceuticals; National Cancer Institute (USA); OBI Pharma
  • Class Antineoplastics; Aziridines; Benzamides; Benzene derivatives; Ethers; Nitro compounds; Phosphorus compounds; Small molecules
  • Mechanism of Action Alkylating agents; DNA cross linking agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Precursor cell lymphoblastic leukaemia-lymphoma; Liver cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Precursor T-cell lymphoblastic leukaemia-lymphoma
  • Phase I/II Liver cancer; Pancreatic cancer; Solid tumours

Most Recent Events

  • 18 Jun 2024 Chemical structure information added
  • 31 May 2024 Efficacy, adverse event and pharmacokinetics data from a phase I/II trial in Solid tumour presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 21 Mar 2024 OBI Pharma terminates a phase I/II trial in Solid tumour and Pancreatic cancer (Late-stage disease, Metastatic disease, Inoperable/Unresectable) in USA (IV), due to lack of sufficient evidence of clinical activity (NCT03592264)

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