Epacadostat - Incyte Corporation

Drug Profile

Epacadostat - Incyte Corporation

Alternative Names: INCB-024360; INCB-24360

Latest Information Update: 14 Sep 2018

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At a glance

  • Originator Incyte Corporation
  • Developer Aduro BioTech; Bristol-Myers Squibb; Columbia University; IMV; Incyte Corporation; MedImmune; Merck AG; Merck Sharp & Dohme; National Cancer Institute (USA); Sidney Kimmel Cancer Center; Stanford University
  • Class Amides; Antineoplastics; Imides; Oxadiazoles; Small molecules
  • Mechanism of Action Indoleamine-pyrrole 2,3-dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Head and neck cancer; Malignant melanoma; Non-small cell lung cancer; Renal cell carcinoma; Urogenital cancer
  • Phase II Fallopian tube cancer; Gastric cancer; Gastrointestinal stromal tumours; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Sarcoma; Solid tumours
  • Phase I/II Cancer; Colorectal cancer; Glioblastoma; Prostate cancer

Most Recent Events

  • 16 Oct 2018 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins plans a phase I trial for Glioblastoma (Recurrent disease, Combination therapy, Second line therapy or greater) (IV) in November 2018 (NCT03707457)
  • 14 Sep 2018 University of Pittsburgh, Incyte Corporation and Merck Sharp & Dohme withdraws a phase Ib/II trial for Colorectal cancer (Metastatic disease, Second-line therapy or greater, Combination therapy) prior to enrolment in the USA (NCT03182894)
  • 02 Aug 2018 National Cancer Institute initiates the QuEST1 phase I/II trial for Solid tumours and Prostate cancer in USA (NCT03493945)
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