Epacadostat - Incyte Corporation

Drug Profile

Epacadostat - Incyte Corporation

Alternative Names: INCB-024360; INCB-24360

Latest Information Update: 03 Aug 2018

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At a glance

  • Originator Incyte Corporation
  • Developer Aduro BioTech; Bristol-Myers Squibb; Columbia University; IMV; Incyte Corporation; MedImmune; Merck AG; Merck Sharp & Dohme; National Cancer Institute (USA); Sidney Kimmel Cancer Center; Stanford University
  • Class Amides; Antineoplastics; Imides; Oxadiazoles; Small molecules
  • Mechanism of Action Indoleamine-pyrrole 2,3-dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Head and neck cancer; Malignant melanoma; Non-small cell lung cancer; Renal cell carcinoma; Urogenital cancer
  • Phase II Fallopian tube cancer; Gastric cancer; Gastrointestinal stromal tumours; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Sarcoma; Solid tumours
  • Phase I/II Cancer; Colorectal cancer; Glioblastoma; Prostate cancer

Most Recent Events

  • 02 Aug 2018 National Cancer Institute initiates the QuEST1 phase I/II trial for Solid tumours and Prostate cancer in USA (NCT03493945)
  • 28 Jul 2018 National Cancer Institute plans a phase II trial for Ovarian Cancer (Recurrent) in USA , (NCT03602586)
  • 20 Jul 2018 Incyte Corporation and Bristol-Myers Squibb terminate a phase III trial in Non-small cell lung cancer (Combination therapy, First-line therapy, Late-stage disease) in USA and Spain (NCT03348904) (EudraCT2017-003304-43)
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