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Varlilumab - Celldex Therapeutics

Drug Profile

Varlilumab - Celldex Therapeutics

Alternative Names: CDX-1127

Latest Information Update: 16 Sep 2019

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At a glance

  • Originator Celldex Therapeutics Inc
  • Developer Celldex Therapeutics Inc; National Cancer Institute (USA); Oncothyreon; University of California at San Francisco; University of Virginia
  • Class Antigens; Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD27 antigen stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Glioblastoma; Malignant melanoma; Non-Hodgkin's lymphoma; Solid tumours
  • Phase I/II Renal cell carcinoma
  • Phase I Glioma
  • No development reported Haematological malignancies; Prostate cancer
  • Discontinued Breast cancer; Ovarian cancer

Most Recent Events

  • 09 Sep 2019 Rutgers and National Cancer Institute plan a phase I trial in Non-small cell lung cancer (Combination therapy, Metastatic disease, Late-stage disease, Second line therapy or greater, Inoperable/Unresectable) in USA (IV) (NCT04081688)
  • 21 Aug 2019 Celldex Therapeutics suspends patient enrolment in a phase II trial in Glioblastoma in USA due to pending new testing requirements from the FDA (IV) (NCT03688178)
  • 08 Aug 2019 Celldex Therapeutics and University of Virginia re-initiates the phase I/II Mel-65 trial for Malignant melanoma (Combination therapy, Late-stage disease, Inoperable/Unresectable) in USA (IV) (NCT03617328)
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