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Alisertib - Takeda Oncology

Drug Profile

Alisertib - Takeda Oncology

Alternative Names: Alsertib; MLN-8237

Latest Information Update: 18 Jan 2019

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At a glance

  • Originator Millennium Pharmaceuticals
  • Developer Fox Chase Cancer Center; Massachusetts General Hospital; Mayo Clinic; Millennium; National Cancer Institute (USA); Northwestern University; Ohio State University Comprehensive Cancer Center; Takeda Oncology; UNC Lineberger Comprehensive Cancer Center; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine; Weill Cornell Medical College; Yale University School of Medicine
  • Class 3-ring heterocyclic compounds; Antineoplastics; Azepines; Benzazepines; Benzoic acids; Fluorobenzenes; Phenyl ethers; Pyrimidines; Small molecules
  • Mechanism of Action Aurora kinase A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; B-cell lymphoma; Brain cancer; Breast cancer; Burkitt's lymphoma; Cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Gastric cancer; Gynaecological cancer; Head and neck cancer; Lymphoma; Mesothelioma; Myelodysplastic syndromes; Myelofibrosis; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Peripheral T-cell lymphoma; Prostate cancer; Small cell lung cancer; Solid tumours

Most Recent Events

  • 27 Jul 2018 The Methodist Hospital System in collaboration with Millenium Pharmaceuticals withdraws a phase I trial prior to enrolment due to lack of funding for Solid tumours (Combination therapy, Second-line therapy of greater) and Lymphoma (Combination therapy, Second-line therapy of greater) in USA (PO) (NCT02780011)
  • 24 Jun 2018 Biomarkers information updated
  • 14 Jun 2018 Safety and efficacy data from a phase I trial in Non-Hodgkin's lymphoma presented at the 23rd Congress of the European Haematology Association (EHA-2018)
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