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Research programme: endopeptidase inhibitors - American Life Science Pharmaceuticals

Drug Profile

Research programme: endopeptidase inhibitors - American Life Science Pharmaceuticals

Alternative Names: acetyl-L-leucyl-L-valyl-L-lysinal-aldehyde; ALP 496; ALSP Next generation compounds; CA 074Me; E 64d

Latest Information Update: 28 Jan 2018

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At a glance

  • Originator American Life Science Pharmaceuticals; Columbia University; University of Illinois at Chicago
  • Class Neuropeptides; Small molecules
  • Mechanism of Action Amyloid precursor protein secretase modulators; Cathepsin B inhibitors; Endopeptidase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Brain injuries
  • No development reported Alzheimer's disease

Most Recent Events

  • 28 Jan 2018 No recent reports of development identified for preclinical development in Alzheimer's-disease in USA
  • 29 Jan 2016 Preclinical development is ongoing in USA
  • 15 Sep 2015 American Life Science Pharmaceuticals establishes CRADA with Walter Reed Army Institute of Research for the development of cathepsin-based therapeutics in Brain Injuries
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