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Inclacumab - Global Blood Therapeutics

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Drug Profile

Inclacumab - Global Blood Therapeutics

Alternative Names: DSM ACC2641; LC1004-002; PF-07940370; R 1512; RG1512; RO 4905417

Latest Information Update: 16 Aug 2024

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At a glance

  • Originator Genmab; Roche
  • Developer Global Blood Therapeutics; Roche
  • Class Anti-inflammatories; Anti-ischaemics; Cardiovascular therapies; Monoclonal antibodies; Vascular disorder therapies
  • Mechanism of Action P selectin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Sickle cell anaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Sickle cell anaemia; Vaso-occlusive crisis
  • Discontinued Acute coronary syndromes; Myocardial infarction; Peripheral vascular disorders

Most Recent Events

  • 06 Jun 2024 Pfizer completes a phase III trial in Vaso-occlusive-crisis (In adolescents, In adults, In children, In the elderly) in Brazil, Colombia, Egypt, Ghana, Nigeria, Oman, Saudi Arabia, Tanzania, Turkey, the UK, Zambia, US, Lebanon, France, Germany and Italy (IV) (NCT04935879)
  • 24 Nov 2023 Pfizer terminates a phase III trial in Vaso-occlusive-crisis (In adolescents, In children, In the elderly, In adults) in USA, Italy, Kenya, Lebanon, Oman, Turkey, Germany, Italy, Brazil, Colombia, France, Nigeria, Saudi Arabia, United Kingdom, Zambia (IV), due to poor accrual and associated recruitment challenges (NCT04927247) (EudraCT2020-005287-60)
  • 05 Oct 2022 Global Blood Therapeutics has been acquired by Pfizer

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