Crenezumab - Genentech

Drug Profile

Crenezumab - Genentech

Alternative Names: Anti-Abeta antibody; Crenezumab; MABT5102A; R 5490245; RG 7412; RO 5490245

Latest Information Update: 26 Jul 2018

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At a glance

  • Originator AC Immune; Universidad de Antioquia
  • Developer AC Immune; Genentech; Universidad de Antioquia
  • Class Antibodies; Antidementias; Monoclonal antibodies
  • Mechanism of Action Amyloid beta-protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Alzheimer's disease

Most Recent Events

  • 25 Jul 2018 Efficacy data from the ABBY and BLAZE phase II trials for Alzheimer's disease released by AC Immune
  • 17 Jul 2018 Roche completes enrolment in the phase III CREAD 2 trial for Alzheimer's disease in Brazil, Chile, Argentina, China, England, Estonia, Israel, Japan, Norway, Peru, Scotland, Serbia, South Africa, Spain, Taiwan, Slovakia, Norway, Netherlands (EudraCT2016-003288-20; NCT03114657)
  • 11 Apr 2018 Roche initiates enrolment in the phase III CREAD OLE trial for Alzheimer's disease in the US and extend to Australia and Canada (NCT03491150)
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