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Research programme: CAR-T cell therapies - TxCell

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Drug Profile

Research programme: CAR-T cell therapies - TxCell

Alternative Names: CAR engineered CD4+ Treg cells - TxCell; CD4+ CD25+ CD45RA+ Tregs; CD45RA+ Tregs; ENTrIA; ENTX-BP; ENTX-LN

Latest Information Update: 28 Apr 2025

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At a glance

  • Originator Weizmann Institute of Science
  • Developer Ospedale San Raffaele; TxCell; University of Lubeck; Weizmann Institute of Science
  • Class CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • No development reported Inflammatory bowel diseases; Multiple sclerosis
  • Discontinued Bullous pemphigoid; Lupus nephritis; Rheumatoid arthritis

Most Recent Events

  • 28 Apr 2025 No recent reports of development identified for preclinical development in Inflammatory-bowel-diseases in France (Parenteral)
  • 28 Feb 2025 No recent reports of development identified for preclinical development in Multiple-sclerosis in France (Parenteral)
  • 28 Feb 2023 CAR-T cell therapies is still in preclinical trial for Inflammatory bowel diseases in France

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