Navitoclax - AbbVie

Drug Profile

Navitoclax - AbbVie

Alternative Names: ABT-263; RG 7423; RG 7433

Latest Information Update: 25 Jul 2018

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At a glance

  • Originator Abbott Laboratories
  • Developer Abbott Laboratories; AbbVie; Genentech
  • Class Antineoplastics; Benzamides; Morpholines; Piperazines; Small molecules; Sulfones
  • Mechanism of Action Bcl-X protein inhibitors; Proto-oncogene protein c-bcl-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Myelofibrosis
  • Phase I Precursor cell lymphoblastic leukaemia-lymphoma
  • Discontinued Chronic lymphocytic leukaemia; Lymphoid leukaemia; Lymphoma; Non-small cell lung cancer; Small cell lung cancer; Solid tumours

Most Recent Events

  • 19 Jul 2018 AbbVie initiates an expanded-access programme for Cancer (NCT03592576)
  • 24 Jun 2018 Biomarkers information updated
  • 14 Jun 2018 Preliminary efficacy data from a phase I trial in Precursor cell lymphoblastic leukaemia-lymphoma presented at the 23rd Congress of the European Haematology Association (EHA-2018)
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