Drug Profile

Rucaparib - pharmaand GmbH

Alternative Names: AG-014699; AG-14699; CO-338; PF-01367338; PF-1367338; Rubraca; Rucaparib phosphate - pharmaand GmbH

Latest Information Update: 17 Sep 2025

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At a glance

Originator Cancer Research UK
Developer Alliance for Clinical Trials in Oncology; Bristol-Myers Squibb; Cancer Research UK; Clovis Oncology; Clovis Oncology [CEASED]; Merck Sharp & Dohme; National Cancer Institute (USA); NHS Greater Glasgow and Clyde; Roche; UNICANCER; University of Colorado at Denver; University of Oklahoma; University of Utah
Class 3-ring heterocyclic compounds; Amines; Antineoplastics; Azepines; Fluorine compounds; Indoles; Small molecules
Mechanism of Action Poly(ADP-ribose) polymerase 2 inhibitors; Poly(ADP-ribose) polymerase 3 inhibitors; Poly(ADP-ribose) polymerase-1 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Ovarian cancer
New Molecular Entity Yes

Marketed Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer
Phase II Breast cancer; Cervical cancer; Endometrial cancer; Gastric cancer; Malignant-mesothelioma; Pancreatic cancer; Small cell lung cancer; Solid tumours; Triple negative breast cancer; Urogenital cancer
Phase I/II Non-small cell lung cancer
Suspended Malignant melanoma
No development reported Gynaecological cancer

30 May 2025 Efficacy and adverse events data from phase III TRITON3 trial in Prostate cancer presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
30 May 2025 Efficacy data from the phase II LODESTAR trial in Solid tumours presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
13 Feb 2025 Updated efficacy and adverse events data from the TRIPTON3 trial in Prostate cancer presented at the 2025 Genitourinary Cancers Symposium (ASCO-GeCS-2024)

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