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Rucaparib

Drug Profile

Rucaparib

Alternative Names: AG-014699; AG-14699; CO-338; PF-01367338; PF-1367338; Rubraca; Rucaparib phosphate

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Cancer Research UK
  • Developer Alliance for Clinical Trials in Oncology; Bristol-Myers Squibb; Cancer Research UK; Clovis Oncology; Clovis Oncology [CEASED]; Merck Sharp & Dohme; National Cancer Institute (USA); NHS Greater Glasgow and Clyde; Roche; UNICANCER; University of Colorado at Denver; University of Oklahoma; University of Utah
  • Class 3-ring heterocyclic compounds; Antineoplastics; Azepines; Indoles; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase 1 inhibitors; Poly(ADP-ribose) polymerase 2 inhibitors; Poly(ADP-ribose) polymerase 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer
  • Phase II Breast cancer; Cervical cancer; Endometrial cancer; Gastric cancer; Malignant-mesothelioma; Pancreatic cancer; Small cell lung cancer; Solid tumours; Triple negative breast cancer; Urogenital cancer
  • Phase I/II Non-small cell lung cancer
  • Suspended Malignant melanoma
  • No development reported Gynaecological cancer

Most Recent Events

  • 12 Oct 2023 The Committee for Medicinal Products for Human Use (CHMP) of the EMA adopts positive opinion recommending approval of rucaparib as maintenance treatment for Ovarian cancer (Late-stage disease, Monotherapy), Peritoneal cancer (Late-stage disease, Monotherapy), and Fallopian tube cancer (Late-stage disease, Monotherapy) who are in response following completion of first-line platinum-based chemotherapy in European Union (PO)
  • 30 Aug 2023 National Cancer Institute suspends a phase-III CASPAR trial for Prostrate cancer (Combination therapy, First-line therapy, Late-stage disease, Metastatic disease) in USA (PO), as data from phase I trial of enzalutamide and rucaparib was being reviewed to determine the need for the PK substudy (NCT04455750)
  • 26 May 2023 Chemical structure information added
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