Rucaparib - Clovis Oncology

Drug Profile

Rucaparib - Clovis Oncology

Alternative Names: AG-014699; AG-14699; CO-338; PF-01367338; PF-1367338; Rubraca; Rucaparib phosphate

Latest Information Update: 01 Aug 2018

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At a glance

  • Originator Cancer Research UK
  • Developer Bristol-Myers Squibb; Cancer Research UK; Clovis Oncology; Ohio State University Comprehensive Cancer Center; Roche; UNICANCER; University of California at San Francisco; University of Oklahoma
  • Class 3-ring heterocyclic compounds; Antineoplastics; Azepines; Indoles; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase III Prostate cancer
  • Phase II Breast cancer; Cervical cancer; Endometrial cancer; Pancreatic cancer; Urogenital cancer
  • Phase I Gynaecological cancer; Solid tumours
  • Suspended Malignant melanoma

Most Recent Events

  • 01 Aug 2018 Clovis Oncology intends to launch Rucaparib in European Union in early 2019
  • 01 Aug 2018 Clovis oncology plans a phase II trial of rucaparib in combination with nivolumab in patients with relapsed, BRCA wild-type ovarian cancer and locally advanced or metastatic bladder carcinoma who are ineligible for treatment with cisplatin (Combination therapy, Late-stage disease) in the second half of 2018
  • 12 Jul 2018 Phase-I clinical trials in Endometrial, Ovarian, Fallopian tube, Peritoneal cancer (Combination therapy, Metastatic disease, Recurrent, Second-line therapy or greater) in USA (PO) (NCT03552471)
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