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Rucaparib - Clovis Oncology

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Drug Profile

Rucaparib - Clovis Oncology

Alternative Names: AG-014699; AG-14699; CO-338; PF-01367338; PF-1367338; Rubraca; Rucaparib phosphate

Latest Information Update: 22 Feb 2019

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At a glance

  • Originator Cancer Research UK
  • Developer Bristol-Myers Squibb; Cancer Research UK; Clovis Oncology; Merck Sharp & Dohme; NHS Greater Glasgow and Clyde; Ohio State University Comprehensive Cancer Center; Roche; UNICANCER; University of California at San Francisco; University of Glasgow; University of Oklahoma; University of Utah
  • Class 3-ring heterocyclic compounds; Antineoplastics; Azepines; Indoles; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase 1 inhibitors; Poly(ADP-ribose) polymerase 2 inhibitors; Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase III Prostate cancer
  • Phase II Breast cancer; Cervical cancer; Endometrial cancer; Pancreatic cancer; Urogenital cancer
  • Phase I/II Non-small cell lung cancer
  • Phase I Gynaecological cancer; Solid tumours
  • Suspended Malignant melanoma

Most Recent Events

  • 19 Feb 2019 Clovis Oncology and Alkermes enter into R&D agreement to evaluate combination of rucaparib with ALKS 4230 and lucitanib
  • 15 Feb 2019 Hoffmann-La Roche plans a phase I/II trial for Beast, Ovarian or Prostate cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in the US, Australia, Italy, South Korea and Spain in March 2019 (NCT03840200)
  • 11 Feb 2019 Clovis Oncology plans the phase II ARIES trial in Ovarian cancer (Late-stage disease, Combination therapy), Urogenital cancer (Unresectable\Inoperable, Metastatic disease disease, Combination therapy) in February 2019 (NCT03824704)
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