Guadecitabine- Astex Pharmaceuticals

Drug Profile

Guadecitabine- Astex Pharmaceuticals

Alternative Names: Decitabine deoxyguanosine; Decitabine deoxyguanosine dinucleotide; S-110; SGI-110

Latest Information Update: 02 Jul 2018

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At a glance

  • Originator SuperGen
  • Developer Astex Pharmaceuticals; AstraZeneca; Big Ten Cancer Research Consortium; Columbia University; Fox Chase Cancer Center; Genentech; Indiana University School of Medicine; John Hopkins University; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); University of Southern California; Weill Cornell Medical College
  • Class Antineoplastics; Aza compounds; Deoxyribonucleosides; Furans; Purine nucleosides; Small molecules; Triazines
  • Mechanism of Action Antimetabolites; DNA cytosine 5 methyltransferase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Phase II Gastrointestinal stromal tumours; Hepatocellular carcinoma; Myeloproliferative disorders; Ovarian cancer; Phaeochromocytoma; Renal cell carcinoma; Solid tumours; Urogenital cancer
  • Phase I/II Bladder cancer; Colorectal cancer; Renal cancer
  • Phase I Cholangiocarcinoma; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Small cell lung cancer
  • No development reported Germ cell and embryonal neoplasms

Most Recent Events

  • 13 Jul 2018 University of Southern California in collaboration with National Cancer Institute, Bristol-Myers Squibb, and Astex Pharmaceuticals plans a phase Ib/II trial in Colorectal cancer (Metastatic disease, Late-sate disease, Second-line therapy or greater, Combination therapy, in combination with Nivolumab) in USA in August 2018 (NCT03576963)
  • 01 Jun 2018 Astex Pharmaceuticals initiates long-term extension trial for Acute myeloid leukaemia, Chronic myelomonocytic leukaemia and Myelodysplastic syndromes worldwide (JapicCTI-184015)
  • 28 May 2018 No recent reports of development identified for phase-I development in Germ-cell-cancer(Combination therapy, Refractory metastatic disease) in USA (SC, Injection)
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